o2ti factories

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Manufacturers must also consider the particle size distribution of titanium dioxide when formulating their products. Finer particles can lead to improved gloss and smoothness, while coarser particles might be preferred for specific textured effects or to reduce costs without compromising on opacity. The surface treatment of titanium dioxide particles is another aspect that can be tailored to enhance compatibility with different types of binders and additives used in paint formulations.

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At the present JECFA meeting, the committee considered additional toxicological studies relevant to the safety assessment of the chemical that investigated its toxicokinetics, acute toxicity, short-term toxicity, long-term toxicity and carcinogenicity, genotoxicity, and reproductive and developmental toxicity, as well as special studies addressing its short-term initiation/promotion potential for colon cancer. The experts acknowledged that a large number of toxicological studies have been conducted using test materials, including nanoparticles, having size distributions and physico-chemical properties not comparable to real-world uses of titanium dioxide as a food additive. The studies on non-representative materials were evaluated by JECFA, but the committee concluded that such studies are not relevant to the safety assessment of the additive.

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